Note

Structure-activity Relationship of Pamamycins: Effect of Side Chain Length on Aerial Mycelium-inducing Activity

Ikuko Kozone, Makoto Hashimoto††, Udo Gräfe, Hiroshi Kawaide, Hiroshi Abe, Masahiro Natsume

Received: December 20, 2007 / Accepted: February 16, 2008
© Japan Antibiotics Research Association

Abstract Two pamamycin homologues with different side chain lengths were isolated from Streptomyces sp. HKI-0118. Aerial mycelium-inducing activity decreased by ca. 1/10 per methylene unit in the side chain.

Keywords pamamycin, structure-activity relationship, aerial mycelium, differentiation, polyketide


M. Natsume (Corresponding author), H. Kawaide, H. Abe: Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu, 183-8509 Tokyo, Japan, E-mail: natsume@cc.tuat.ac.jp
I. Kozone, M. Hashimoto: United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu, 183-8509 Tokyo, Japan
U. Gräfe: Hans-Knöll-Institute of Natural Products Research, Jena, Germany
Present address: Chemical Biology Team, Biological Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), Aomi, Koto-ku, Tokyo 135-0064, Japan
†† Present address: Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan