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Chrysogenamide A from an Endophytic Fungus Associated with Cistanche deserticola and Its Neuroprotective Effect on SH-SY5Y Cells

Zhenjian Lin, Jiangni Wen, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, Weiming Zhu

Received: November 12, 2007 / Accepted: January 15, 2008
© Japan Antibiotics Research Association

Abstract Chrysogenamide A (1), a new member of the macfortine group of alkaloids, along with four known compounds (2~5) were identified from Penicillium chrysogenum No. 005, an endophytic fungus associated with Cistanche deserticola Y. C. Ma. The new structure was elucidated on the basis of comprehensive spectral analysis. 1 exhibited a neurocyte protection effect against oxidative stress-induced cell death in SH-SY5Y cells.

Keywords chrysogenamide A; endophyte; Penicillium chrysogenum; Cistanche deserticola; neurocyte protection; marcfortine alkaloids


Q. Gu, W. Zhu (Corresponding author), Z. Lin, J. Wen, T. Zhu, Y. Fang: Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.R. China,
E-mail: guqianq@ouc.edu.cn and weimingzhu@ouc.edu.cn