Verticillin G, a New Antibacterial Compound from Bionectra byssicola

Chang-Ji Zheng, Soo-Hee Park, Hiroyuki Koshino, Young-Ho Kim, Won-Gon Kim

Received: July 31, 2006 / Accepted: December 1, 2006
© Japan Antibiotics Research Association

Abstract A new epidithiodioxopiperazine compound named verticillin G along with the known compound verticillin D has been isolated from the mycelium of liquid fermentation cultures of a fungal strain Bionectra byssicola F120. The structure of verticillin G was determined on the basis of MS and NMR data. Verticillin G inhibited the growth of Staphylococcus aureus including methicillin-resistant and quinolone-resistant S. aureus with MIC (μg/ml) of 3~10.

Keywords v erticillin G, epidithiodioxopiperazine, anti-MRSA, Bionectra byssicola

W.-G. Kim (Corresponding author), C.-J. Zheng, S.-H. Park: Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Daejeon 305-600, Republic of Korea, E-mail:
Y.-H. Kim: Chungnam National University, College of Pharmacy, Daejeon 305-764, Republic of Korea
H. Koshino: Molecular Characterization Team, RIKEN, Hirosawa 2-1, Wako, Saitama 351-0198, Japan