Bromoalterochromides A and A´, Unprecedented Chromopeptides from a Marine Pseudoalteromonas maricaloris Strain KMM 636T†

Michael Speitling, Olga F. Smetanina, Tatyana A. Kuznetsova, Hartmut Laatsch

Received: August 18, 2006 / Accepted: December 21, 2006
© Japan Antibiotics Research Association

Abstract The marine strain Pseudoalteromonas maricaloris KMM 636T was found to produce an inseparable mixture of two brominated yellow main pigments, bromoalterochromide A and A´, in a ratio of 3 : 1. Both pigments are Thr-Val-Asn-Asn-X pentapeptide lactones, where the amino group of Thr is acylated with 9-(3-bromo-4-hydroxyphenyl)-nona-2,4,6,8-tetraenoic acid, and X is aIle and Leu, respectively. They possess cytotoxic effects on developing eggs of the sea urchin Strongylocentrotus intermedius, but no antibiotic activity.

Keywords bromoalterochromide, chromopeptide, peptide lactone, Pseudoalteromonas maricaloris

H. Laatsch (Corresponding author), M. Speitling: Department of Organic and Biomolecular Chemistry, University of Gottingen, Tammannstrasse 2, D-37077 Gottingen, Germany, E-mail hlaatsc@gwdg.de
T. Kuznetsova, O. Smetanina: Pacific Institute of Bioorganic Chemistry, pr. 100 let Vladivostoku 159, 690022 Vladivostok (Russia)
Art. No. XXXV on Marine Bacteria. Art. XXXIV: H. M. P. Poumale, B. T. Ngadjui, E. Helmke, H. Laatsch: Marine bacteria, XXXIV: New anthraquinones from a marine Streptomyces sp. isolation, structure determination and biological activities. Z. Naturforsch. B, accepted August 2006