1-Deoxynojirimycin Derivatives from the Marine Sponge Lendenfeldia chondrodes

Ryuichi Sakai, Hisao Kamiya

Dedicated to the memory of Professor Kenneth L. Rinehart.

Received: May 30, 2006 / Accepted: August 15, 2006
© Japan Antibiotics Research Association

Abstract Two 1-deoxynojirimycin derivatives, 1-deoxynojirimycin-6-phosphate (1) and N-methyl-1-deoxynojirimycin-6-phosphate (2) were isolated from an aqueous extract of Micronesian marine sponge Lendenfeldia chondrodes for the first time as natural products. Structures of these compounds were assigned on the basis of their spectral data and chemical degradation.

Keywords deoxynojirimycin, α-glucosidase inhibitor, marine sponge, Lendenfeldia

R. Sakai (Corresponding author), H. Kamiya: Kitasato University School of Fisheries Sciences, Sanriku-cho, Ofunato Iwate 022-0101, Japan, E-mail: r.sakai@kitasato-u.ac.jp