Sporminarins A and B: Antifungal Metabolites from a Fungicolous Isolate of Sporormiella minimoides

Sanjay V. Mudur, James B. Gloer, Donald T. Wicklow

This manuscript is dedicated to the late Professor Kenneth L. Rinehart, Jr. of the University of Illinois in honor of his many contributions to our field.

Received: June 1, 2006 / Accepted: August 16, 2006
© Japan Antibiotics Research Association

Abstract Cultures of a fungicolous isolate of Sporormiella minimoides afforded two new polyketide metabolites which we have named sporminarins A (1) and B (2). The planar structures of 1 and 2 were elucidated by analysis of NMR and MS data, and by chemical methods. 1 exhibited significant antifungal activity against Aspergillus flavus.

Keywords sporminarins, antifungal, Sporormiella minimoides

J. B. Gloer (Corresponding author), S. V. Mudur: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242,
E-mail: james-gloer@uiowa.edu.
D. T. Wicklow: Mycotoxin and Crop Bioprotection Research Units, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA, Peoria, Illinois 61604