Tensidols, New Potentiators of Antifungal Miconazole Activity, Produced by Aspergillus niger FKI-2342

Takashi Fukuda, Yoko Hasegawa, Keiichi Hagimori, Yuichi Yamaguchi, Rokuro Masuma, Hiroshi Tomoda, Satoshi O_Bold_long.gif"mura

Dedicated to the memory of Professor Kenneth L. Rinehart.

Received: June 2, 2006 / Accepted: August 7, 2006
© Japan Antibiotics Research Association

Abstract Two new furopyrrols, designated tensidols A and B, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated and shown to have the common skeleton of 6-benzyl-6H-furo[2,3-b]pyrrole. Tensidols A and B potentiated miconazole activity against Candida albicans. Tensidols also showed moderate antimicrobial activity only against Pyricularia oryzae.

Keywords tensidol, miconazole potentiator, Aspergillus niger, furopyrrol, fungal metabolite, Candida albicans

H. Tomoda (Corresponding author): School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, E-mail: tomodah@pharm.kitasato-u.ac.jp
Y. Yamaguchi, S. O_long.gif"mura: The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
T. Fukuda, Y. Hasegawa, K. Hagimori, R. Masuma: Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan