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Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065

Akira Mukai, Toshio Fukai, Yuko Matsumoto, Jun Ishikawa, Yasutaka Hoshino, Katsukiyo Yazawa, Ken-ichi Harada, Yuzuru Mikami

Received: April 27, 2006 / Accepted: June 9, 2006
© Japan Antibiotics Research Association

Abstract Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity against Gram-negative bacteria, fungi and tumor cells.

Keywords transvalencin Z, siderophores, Nocardia transvalensis, nocobactin


Y. Mikami (Corresponding author), A. Mukai, Y. Matsumoto, K. Yazawa: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan, E-mail: mikami@faculty.chiba-u.jp
T. Fukai: School of Pharmaceutical Sciences, Toho University,
2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
J. Ishikawa, Y. Hoshino: Department of Bioactive Molecules, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
K. Harada: Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan