N-Carboxamido-staurosporine and Selina-4(14),7(11)-diene-8,9-diol, New Metabolites from a Marine Streptomyces sp.

Shao Jie Wu, Serge Fotso, Fuchao Li, Song Qin, Gerhard Kelter, Heinz H. Fiebig, Hartmut Laatsch

Received: May 9, 2006 / Accepted: May 19, 2006
© Japan Antibiotics Research Association

Abstract In our screening of micro-organisms for novel bioactive natural products, a new staurosporinone, N-carboxamido-staurosporine (1c), and a new sesquiterpene, (5S,8S,9R,10S)-selina-4(14),7(11)-diene-8,9-diol (2a), were isolated from the culture broth of the marine-derived Streptomyces sp. QD518. Their structures were determined by spectroscopic methods and by comparison of the NMR data with those of structurally related known natural products, which were isolated from the same strain.

Keywords marine streptomycete, staurosporine, selinane sesquiterpene

H. Laatsch (Corresponding author), S. J. Wu, S. Fotso: Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany,
E-mail: HLAATSC@gwdg.de
S. J. Wu, F. Li, S. Qin: Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, P.R. China
S. J. Wu, F. Li: Graduate School of Chinese Academy of Science, Beijing, 100049, P.R. China
G. Kelter, H. H. Fiebig: Oncotest GmbH, Am Flughafen 12-14, D-79108 Freiburg, Germany
Art. No. XXXI on Marine Bacteria. Art. XXX: S. J. Wu, S. Fotso, F. Li, S. Qin, H. Laatsch. New amorphane sesquiterpenes from a marine Streptomyces sp. J. Nat. Prod., submitted 9/2005.