Received: March 6, 2006 / Accepted: April 7, 2006
© Japan Antibiotics Research Association
Abstract A new nucleoside derivative, AJP117510 (1) was isolated from unidentified fungus AJ117510. The structure of 1 was elucidated by spectroscopic analyses. Nucleoside 1 inhibited the binding of integrin α2β1 to collagen in a dose dependent manner with an IC50 value of 5.9 μM.
Keywords AJP117510, integrin α2β1, collagen, inhibitor, nucleoside
S. Sato (Corresponding author), F. Futaki, N. Fukuchi, K. Kaida, M. Hiraga, S. Kobaru, T. Tsuji: Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki 210-8681, Japan, E-mail: firstname.lastname@example.org
† Present address: AminoScience Laboratories
†† Present address: Institute of Life Sciences