Augmentation of Cellular Immunity by Kigamicin D

Toru Masuda, Shunichi Ohba, Manabu Kawada, Masatomi Iijima, Hiroyuki Inoue, Michiyo Osono, Daishiro Ikeda, Setsuko Kunimoto

Received: December 16, 2005 / Accepted: March 29, 2006
© Japan Antibiotics Research Association

Abstract Kigamicin D did not show any immunosuppressive activity in mixed lymphocyte culture reaction and mitogen induced lymphocyte blastogenesis in vitro and graft versus host reaction in vivo. Natural killer cell activity in spleen cells was not affected by oral administration of kigamicin D. Instead, delayed-type hypersensitivity response to sheep red blood cells was stimulated at a broad dosage level. It is concluded that kigamicin D increases cellular immunity to specific antigen.

Keywords kigamicin D, cellular immunity, delayed-type hypersensitivity

T. Masuda (Corresponding author), S. Ohba, M. Kawada, M. Iijima, H. Inoue, M. Osono, D. Ikeda, S. Kunimoto: Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan, E-mail: masudat@bikaken.or.jp