Oxachelin, a Novel Iron Chelator and Antifungal Agent from Streptomyces sp. GW9/1258

Bernd Sontag, Martin Gerlitz, Thomas Paululat, Hans-Falk Rasser, Iris Grün-Wollny, Friedrich G. Hansske

Received: June 20, 2006 / Accepted: October 10, 2006
© Japan Antibiotics Research Association

Abstract During a screening campaign for new antimicrobial and antifungal secondary metabolites from several thousand actinomycetes, a novel compound, isolated by activity guided fractionation, was oxachelin (1) from the new Streptomyces sp. GW9/1258. Oxachelin shows strong antibiotic activities against several fungi and gram(+) bacteria. Additionally, oxachelin is a strong complexing ligand for Fe3+ (siderophore), possibly making it useful e.g. for iron excess diseases.

Keywords oxachelin, antifungal agents, iron chelator, Streptomyces, microbial products

B. Sontag (Corresponding author), H.-F. Rasser, I. Grün-Wollny, F. G. Hansske: BioFocus DPI GmbH, Waldhofer Str. 104, D-69123 Heidelberg, Germany
E-mail: bernd.sontag@glpg.com
M. Gerlitz: Sanofi-Aventis, Natural Products Research, Industriepark Höchst, D-65926 Frankfurt/Main, Germany
T. Paululat: University of Siegen, FB8/OC-II, Adolf-Reichwein-Str. 2, D-57068 Siegen, Germany