Received: June 29, 2006 / Accepted: October 6, 2006
© Japan Antibiotics Research Association
Abstract New nine insecticidal antibiotics designated yaequinolones were isolated from the culture broth of the fungal strain Penicillium sp. FKI-2140 by solvent extraction, centrifugal partition chromatography and HPLC. Yaequinolones showed growth inhibitory activity against brine shrimp (Artemia salina). Among them, yaequinolone F has the most potent activity with MIC value of 0.19 μg/ml.
Keywords yaequinolone, insecticidal, brine shrimp (Artemia salina), fungi, Penicillium sp.
H. Tomoda (Corresponding author), R. Uchida: School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, E-mail: email@example.com
R. Imasato, Y. Yamaguchi, R. Masuma, S. mura: Kitasato Institute for Life Sciences, & Graduate School of Infection Control Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan