Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341

II. Physicochemical Properties and Structure Determination

Won-Gon Kim, Tae Mi Yoon, Hyung Jin Kwon, Joo Won Suh

Received: June 9, 2006 / Accepted: October 3, 2006
© Japan Antibiotics Research Association

Abstract In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides with potent antifungal activity, talosins A and B, were isolated from the culture broth of Kitasatospora kifunensis MJM341. Talosins A and B were determined to be genistein 7-α-L-6-deoxy-talopyranoside and genistein 4´,7-di-α-L-6-deoxy-talopyranoside, respectively, by spectroscopic studies. They are the first flavonoid glycosides incorporating 6-deoxy-talose as a sugar component.

Keywords Kitasatospora kifunensis, antifungal agent, isoflavonol glycoside, genistein, 6-deoxy-talose, talosin A, talosin B

J. W. Suh (Corresponding author), T. M. Yoon, H. J. Kwon: Institute of Bioscience and Biotechnology, Department of Biological Science, Myongji University, Yongin, Gyeonggi-Do, 449-728, Korea, E-mail: jwsuh@mju.ac.kr
W.-G. Kim: Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong-Gu, Daejeon, 305-600, Korea
T. M. Yoon, J. W. Suh: Extract Collection of Useful Microorganism (ECUM), 2229 Beakmagwan, Myongji University, Yongin, Gyeonggi-Do, 449-728, Korea
These authors contributed equally to this study.