Note

Ushikulides A and B, Immunosuppressants Produced by a Strain of Streptomyces sp.

Kosaku Takahashi, Teruhiko Yoshihara, Kazuhiko Kurosawa

Received: April 27, 2005 / Accepted: June 1, 2005
© Japan Antibiotics Research Association

Abstract Novel immunosuppressants, ushikulides A and B, were isolated from the culture broth of Streptomyces sp. IUK-102. Ushikulides A and B both have the same molecular formula, determined as C40H68O10. The structures of both compounds were elucidated to be novel 22-membered macrolides. Both compounds showed immunosuppressive activity for murine splenocyte proliferation in vitro.

Keywords 22-membered macrolides, ushikulide, immunosuppressants


K. Takahashi (Corresponding author), T. Yoshihara: Graduate School of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan, E-mail: kosaku@chem.agr.hokudai.ac.jp
K. Kurosawa: Department of Biology 68-370, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA