Note

Circumdatin H, a New Inhibitor of Mitochondrial NADH Oxidase, from Aspergillus ochraceus

M. Pilar López-Gresa, M. Carmen González, Jaime Primo, Pilar Moya,
Vanessa Romero, Ernesto Estornell

Received: March 24, 2005 / Accepted: June 1, 2005
© Japan Antibiotics Research Association

Abstract Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.

Keywords Aspergillus ochraceus, alkaloids, benzodiazepine, circumdatin, flavacol, stephacidin A, mitochondrial respiratory chain inhibitors


M. P. López-Gresa (Corresponding author), M. C. González, J. Primo, P. Moya: Centro de Ecología Química Agrícola, Universidad Politénica de Valencia, Campus de Vera, Edificio 9B, Laboratorio 111, 46022 Valencia, Spain, E-mail: mplopez@ceqa.upv.es
V. Romero, E. Estornell: Departament de Bioquíica i Biologia Molecular, Facultat de Farmàcia, Universitat de València, Avgda Vicent Andrés Estellés/n, 46100 Burjassot (València), Spain