Note

New 24-Membered Macrolides SPA-6952A and B Produced by Streptomyces sp.

Nobuo Hosotani, Kazuo Kumagai, Hiroyuki Nakagawa, Takuro Shimatani, Ikutaro Saji

Received: April 13, 2005 / Accepted: May 26, 2005
© Japan Antibiotics Research Association

Abstract Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.

Keywords macrolide, cytotoxic activity, antimicrobial activity, Streptomyces


N. Hosotani (Corresponding author), K. Kumagai, T. Shimatani, I. Saji: Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan, E-mail: hosotani@sumitomopharm.co.jp
H. Nakagawa: Genomic Science Laboratories, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan