Original Article

New Sesquicillins, Insecticidal Antibiotics Produced by Albophoma sp. FKI-1778

Ryuji Uchida, Rie Imasato, Yuichi Yamaguchi, Rokuro Masuma, Kazuro Shiomi, Hiroshi Tomoda, Satoshi O_Bold_long.gif"mura

Received: April 14, 2005 / Accepted: June 9, 2005
© Japan Antibiotics Research Association

Abstract Four new antibiotics, sesquicillins B to E were isolated from the culture broth of Albophoma sp. FKI-1778 together with known sesquicillin (sesquicillin A in this paper). The structures of sesquicillins were elucidated by spectroscopic studies including various NMR experiments. All sesquicillins have a common pyrano-diterpene skeleton. Sesquicillins showed moderate inhibitory activity against the growth of Artemia salina (brine shrimps) and Jurkat cells.

Keywords sesquicillins, insecticidal, antibiotic, fungal metabolites, Albophoma sp., pyrano-diterpene skeleton


H. Tomoda (Corresponding author), K. Shiomi: School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, E-mail: tomoda@lisci.kitasato-u.ac.jp
R. Uchida, R. Imasato, Y. Yamaguchi, R. Masuma, S. O_Bold_long.gif"mura: The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, and Kitasato Institute for Life Sciences, & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan